JOSEPH J. DUDEK, M.D.; ROBERT M. HEANEY, M.D.
To the editor: In the february issue, anthonisen and colleagues (1) described a randomized, double-blinded, crossover trial of antibiotics or placebo in the treatment of exacerbations of chronic obstructive pulmonary disease. We congratulate them on a well-designed and conducted study that addresses a common clinical problem. Although well reported, however, their article raised several specific questions.
The authors discussed their criteria for the onset and resolution of exacerbations. We agree with their choice of patient symptoms and are encouraged by their kappa scores, which are consistently above 0.51 for the 3 key symptoms (increased dyspnea, increased sputum production, change in
Learn more about subscription options.
Register Now for a free account.
DUDEK JJ, HEANEY RM. Antibiotics or Placebo for Chronic Obstructive Pulmonary Disease. Ann Intern Med. 1987;107:117-118. doi: 10.7326/0003-4819-107-1-117
Download citation file:
Published: Ann Intern Med. 1987;107(1):117-118.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only