J. REDON, M.D.; J. M. PASCUAL, M.D.; J. MICHAVILA, M.D.; A. BELDA, M.D.
To the editor: Drug fever is an underdiagnosed situation in part due to nonspecific clinical characteristics as reported by Mackowiak and LeMaistre (1). They wrote that ". . . any drug has the capacity to induce fever. . . . the list is a dynamic one. . . ." We have seen fever as the sole feature of adverse drug reaction by another two drugs not listed by them, (+)-cyanidanol-3 and azathioprine.
(+)-Cyanidanol-3 is a flavonoid used to treat chronic liver disease (2), which induces fever, probably by an immunologic mechanism (3). We have previously reported (4) two men with
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REDON J, PASCUAL JM, MICHAVILA J, BELDA A. Drug Fever. Ann Intern Med. 1987;107:264. doi: 10.7326/0003-4819-107-2-264_1
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Published: Ann Intern Med. 1987;107(2):264.
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