CORNELlS HALMA, M. D.; JAN B. M. J. JANSEN, M.D., Ph.D.; A. ROELOF JANSSENS, M.D., Ph.D.; GERRIT GRIFFIOEN, M.D.; CORNELIS B. H. W. LAMERS, M.D., Ph.D.
▸Requests for reprints should be addressed to Cornells Halma, M.D.; Department of Gastroenterology, Building 1, C4-P, University Hospital Leiden, P. O. Box 9600; 2300 RC Leiden, the Netherlands.
HALMA C, JANSEN JBMJ, JANSSENS AR, GRIFFIOEN G, LAMERS CBHW. Life-Threatening Water Intoxication During Somatostatin Therapy. Ann Intern Med. 1987;107:518-520. doi: 10.7326/0003-4819-107-4-518
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Published: Ann Intern Med. 1987;107(4):518-520.
Short-term infusion (2 hours) of somatostatin has been shown to reduce urinary volume and free-water clearance in healthy persons (1). Although somatostatin is being widely used (2), water intoxication has not been described as a side effect. We report two cases of marked water retention and hyponatremia that occurred in patients receiving somatostatin therapy (given in continuous intravenous infusion at a rate of 250 μg/h after a loading dose of 250 μg). One patient had to be treated with hypertonic saline for hypo-osmolar coma.
Patient 1, a 44-year-old woman with multiple endocrine neoplasia, type 1, had had an insulinoma and
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Endocrine and Metabolism, Nephrology, Fluid and Electrolyte Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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