DIANA R. DECOSIMO, M.D.; SHIH-LIEH FANG, Ph.D.; LEWIS E. BRAVERMAN, M.D.
DECOSIMO DR, FANG S, BRAVERMAN LE. Prevalence of Familial Dysalbuminemic Hyperthyroxinemia in Hispanics. Ann Intern Med. 1987;107:780-781. doi: 10.7326/0003-4819-107-5-780_2
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Published: Ann Intern Med. 1987;107(5):780-781.
To the editor: Familial dysalbuminemic hyperthyroxinemia is a recently recognized autosomal dominant syndrome often confused with thyrotoxicosis in laboratory tests (1-3). This syndrome is characterized by elevations in the serum thyroxine concentration, free thyroxine index, and free thyroxine concentration measured by radioimmunoassay using 125I-labeled thyroxine analogs (4) and normal serum triiodothyronine concentrations, due to a serum albumin that preferentially binds thyroxine and, rarely, triiodothyronine or reverse triiodothyronine (5). However, serum free thyroxine concentrations measured by equilibrium dialysis or by radioimmunoassay using tracer 125I-thyroxine are normal and the patients are euthyroid with normal thyroid suppression tests and basal and thyrotrophin-releasing-hormone-stimulated serum
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