GILAD S. GORDON, M.D.; WILLIAM E. HATHAWAY, M.D.; WILLIAM A. ROBINSON, M.D., Ph.D.
GORDON G., HATHAWAY W., ROBINSON W.; Lack of Effectiveness of Intranasal Administration of Human Factor VIII. Ann Intern Med. 1987;107:788. doi: 10.7326/0003-4819-107-5-788_1
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Published: Ann Intern Med. 1987;107(5):788.
To the editor: In light of recent reports of administration of insulin and other proteins via the nasal route (1-3), we studied the intranasal administration of human factor VIII:C to severe hemophiliacs. We used the adjuvant taurodeoxycholate, which had been shown to be active with insulin (3). We studied four patients, all with severe hemophilia as defined by basal factor VIII levels less than 1%. These patients had not self-administered factor VIII for at least 7 days. They were given 1000 to 2000 units of anti-hemophiliac factor as a fine mist spray in a solution of 1% taurodeoxycholate over a
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