Leonard C. Altman, MD; Penny E. Petersen, MD
To the Editor: The incidence of adverse systemic reactions to iron dextran is 3%; that of life-threatening reactions is 0.6% (1). We present a method for desensitization before iron dextran administration.
A 26-year-old white man had chronic malabsorption and gastrointestinal blood loss resulting in iron deficiency anemia. His hematocrit was maintained at approximately 25 by frequent transfusions; his serum ferritin was 20 ng/mL (normal range, 25 to 100). Because he was unable to absorb oral iron, intravenous iron dextran therapy was attempted. After a test dose of 0.25 mL, he rapidly developed nausea, vomiting, pruritus, diffuse erythema, and tachycardia. Approximately
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Altman LC, Petersen PE. Successful Prevention of an Anaphylactoid Reaction to Iron Dextran. Ann Intern Med. 1988;109:346–347. doi: 10.7326/0003-4819-109-4-346
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Published: Ann Intern Med. 1988;109(4):346-347.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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