Abigail Zuger, MD; Michael Schuster, MD; Michael S. Simberkoff, MD; James J. Rahal, MD; Robert S. Holzman, MD
Zuger A, Schuster M, Simberkoff MS, Rahal JJ, Holzman RS. Maintenance Amphotericin B for Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1988;109:592-593. doi: 10.7326/0003-4819-109-7-592
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Published: Ann Intern Med. 1988;109(7):592-593.
We previously reported our experience (1) with the treatment of cryptococcal infections in patients with the acquired immunodeficiency syndrome (AIDS). Like other investigators (2, 3) we noted a high relapse rate and a poor response to treatment among patients with relapsed infections. Continued weekly infusions of amphotericin B after a standard course of therapy seemed to offer our patients some protection against relapse. Of seven patients who received maintenance therapy with amphotericin B, none had relapses; four of eight patients had relapses when maintenance therapy was not administered. This observation prompted us to recommend maintenance amphotericin B for all patients
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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