Edward N. Robinson, MD; Ronald Fogel, MD
Robinson EN, Fogel R. SMS 201-995, A Somatostatin Analogue, and Diarrhea in the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1988;109:680-681. doi: 10.7326/0003-4819-109-8-680
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Published: Ann Intern Med. 1988;109(8):680-681.
To the Editor: One manifestation of the acquired immunodeficiency syndrome (AIDS) is noninfectious, unremitting diarrhea and accompanying weight loss of unknown cause (1). Somatostatin inhibits pathologic secretion in the human intestine and also improves the secretory diarrhea of patients with AIDS who are colonized with Cryptosporidia species (2-5). We evaluated SMS 201-995, a long-acting somatostatin analogue (Sandoz, Inc., East Hanover, New Jersey) as a therapeutic approach for refractory AIDS-associated wasting and diarrhea without demonstrable cryptosporidial infestation.
A 27-year-old homosexual man, with antibodies to HIV, was evaluated in March 1987 for weight loss, watery diarrhea, urgency, and fecal incontinence. He was
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