Edward N. Robinson Jr., MD; Ronald Fogel, MD
To the Editor: One manifestation of the acquired immunodeficiency syndrome (AIDS) is noninfectious, unremitting diarrhea and accompanying weight loss of unknown cause (1). Somatostatin inhibits pathologic secretion in the human intestine and also improves the secretory diarrhea of patients with AIDS who are colonized with Cryptosporidia species (2-5). We evaluated SMS 201-995, a long-acting somatostatin analogue (Sandoz, Inc., East Hanover, New Jersey) as a therapeutic approach for refractory AIDS-associated wasting and diarrhea without demonstrable cryptosporidial infestation.
A 27-year-old homosexual man, with antibodies to HIV, was evaluated in March 1987 for weight loss, watery diarrhea, urgency, and fecal incontinence. He was
Learn more about subscription options.
Register Now for a free account.
Robinson EN, Fogel R. SMS 201-995, A Somatostatin Analogue, and Diarrhea in the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1988;109:680–681. doi: 10.7326/0003-4819-109-8-680
Download citation file:
Published: Ann Intern Med. 1988;109(8):680-681.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only