Jonathan Leor, MD; Shlomo Matetzki, MD
Leor J, Matetzki S. Ofloxacin and Warfarin. Ann Intern Med. 1988;109:761. doi: 10.7326/0003-4819-109-9-761_1
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Published: Ann Intern Med. 1988;109(9):761.
Ofloxacin, a new 4-quinolone derivative that can be administered orally, has a broad spectrum of activity against many important aerobic and anaerobic pathogens. We report a case of dangerously excessive anticoagulation in a patient given ofloxacin while she was receiving warfarin therapy.
A 40-year-old woman had mitral valve replacement. After the operation, she was treated with digoxin, furosemide, spironolactone, prednisone, verapamil, and warfarin (5 mg daily). Her international normalized ratio was 2:5, and was well controlled and within the therapeutic range (2:3) for the next postoperative course.
Ten days after surgery, a wound infection at the cannulation site of the
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