Werner Hunstein, MD; Lorenz H. Trümper, MD; Reinhard Dummer, MD; Karl Schwechheimer, MD
Glucagonoma syndrome is a rare but well-defined clinical entity caused by the excessive production of glucagon in an alpha cell tumor of the pancreas. The principal features of this syndrome, apart from a considerably elevated glucagon serum level, include a typical skin rash (necrolytic migratory erythema), diabetes mellitus or impaired glucose tolerance, weight loss, and anemia. The first case was reported by Becker and associates in 1942 (1), but the association of ectopic glucagon production and necrolytic erythema was defined as Glucagonoma syndrome as late as 1974 by Mallinson and colleagues (2).
More than 120 cases have been described, allowing
Learn more about subscription options.
Register Now for a free account.
Hunstein W, Trümper LH, Dummer R, Schwechheimer K. Glucagonoma Syndrome and Bronchial Carcinoma. Ann Intern Med. 1988;109:920-921. doi: 10.7326/0003-4819-109-11-920
Download citation file:
Published: Ann Intern Med. 1988;109(11):920-921.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Lung Cancer, Pancreatic Cancer.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only