Werner Hunstein, MD; Lorenz H. Trümper, MD; Reinhard Dummer, MD; Karl Schwechheimer, MD
Glucagonoma syndrome is a rare but well-defined clinical entity caused by the excessive production of glucagon in an alpha cell tumor of the pancreas. The principal features of this syndrome, apart from a considerably elevated glucagon serum level, include a typical skin rash (necrolytic migratory erythema), diabetes mellitus or impaired glucose tolerance, weight loss, and anemia. The first case was reported by Becker and associates in 1942 (1), but the association of ectopic glucagon production and necrolytic erythema was defined as Glucagonoma syndrome as late as 1974 by Mallinson and colleagues (2).
More than 120 cases have been described, allowing
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Hunstein W, Trümper LH, Dummer R, Schwechheimer K. Glucagonoma Syndrome and Bronchial Carcinoma. Ann Intern Med. 1988;109:920–921. doi: 10.7326/0003-4819-109-11-920
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Published: Ann Intern Med. 1988;109(11):920-921.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Lung Cancer, Pancreatic Cancer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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