Thomas G. Cantu, PharmD; David Fantozzi, RPh
Cantu TG, Fantozzi D. Cefuroxime Dosage in Renal Failure. Ann Intern Med. 1988;109:989-990. doi: 10.7326/0003-4819-109-12-989_2
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Published: Ann Intern Med. 1988;109(12):989-990.
To the Editor: Drug Prescribing in Renal Failure by Bennett and colleagues (1) possibly contains a misprint. This excellent reference provides dosage recommendations for various drugs when prescribed for patients with differing degrees of renal dysfunction.
For patients with an estimated glomerular filtration rate of less than 10 mL/min, Bennett and colleagues recommend 5%-10% of the usual intravenous cefuroxime dosage. If the usual dose of 750 mg is given every 8 hours, patients will receive 112 to 225 mg daily. Ten percent of the dosage for life-threatening infections (1.5 g every 6 hours) provides 600 mg daily. In contrast, the
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