Anthony L. Komaroff, MD; Stephen E. Straus, MD; Nelson M. Gantz, MD; James F. Jones, MD
Komaroff AL, Straus SE, Gantz NM, Jones JF. The Chronic Fatigue Syndrome. Ann Intern Med. 1989;110:407-408. doi: 10.7326/0003-4819-110-5-407
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Published: Ann Intern Med. 1989;110(5):407-408.
To the Editor: Manu and colleagues (1) recently reported that a large proportion of self-selected patients with chronic fatigue have various psychiatric conditions, as determined by the application of a structured interview, the Diagnostic Interview Schedule (DIS), and that only a few patients had well-recognized organic illnesses.
We agree that primary psychiatric disease is common in patients with fatigue and that only an occasional patient seeking medical care for chronic fatigue has a well-recognized organic illness, such as an occult malignancy. We believe that there is another disorder, the chronic fatigue syndrome, that is also likely to be an organic
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