J. A. del Olmo, MD; J. V. Bagan; J. M. Rodrigo; M. A. Serra; A. H. Wassel; L. Aparisi; M. Bixquert
del Olmo JA, Bagan JV, Rodrigo JM, Serra MA, Wassel AH, Aparisi L, et al. Oral Lichen Planus and Hepatic Cirrhosis. Ann Intern Med. 1989;110:666. doi: 10.7326/0003-4819-110-8-666_1
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Published: Ann Intern Med. 1989;110(8):666.
To the Editor: Recent reports have described the association of chronic liver disease and lichen planus (13); however, there is uncertainty about the prevalence of chronic liver disease in patients with lichen planus (4, 5). We carried out a prospective study of 65 patients diagnosed macro- and microscopically as having oral lichen planus. Each patient was examined and a complete medical history including information about the ingestion of potentially hepatotoxic drugs was obtained. Each patient was tested for transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase, protein, and serologic markers for hepatitis B virus. When we suspected chronic liver disease because of hepatosplenomegaly
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