Sylvie Chollet-Martin, MD; Jacques Fricker, MD; Marian Apfelbaum, MD; Marie-Anne Gougerot-Pocidalo, MD
Chollet-Martin S, Fricker J, Apfelbaum M, Gougerot-Pocidalo M. Tumor Necrosis Factor and Obesity. Ann Intern Med. 1989;110:666-667. doi: 10.7326/0003-4819-110-8-666_2
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Published: Ann Intern Med. 1989;110(8):666-667.
To the Editor: Although its role is not fully known, tumor necrosis factor (TNF) or cachectin would appear to be involved in determining nutritional status. In effect, the administration of recombinant human TNF (rTNF) to rodents causes decreases in food intake and body weight (1, 2). In humans, rTNF given in antineoplastic trials induced anorexia and various metabolic effects including increased whole body lipolysis and fat utilization (1). Given the likely involvement of TNF in the pathophysiology of cachexia, we sought a possible relationship between TNF metabolism and the inverse nutritional disorder, obesity.
Plasma TNF levels were assayed in 16
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