Terry Linville, MD; Dean Matanin, PharmD
To the Editor: Norfloxacin (Noroxin, Merck Sharp & Dohme, West Point, Pennsylvania) was the first of the fluorinated quinolone group of antimicrobial agents to be released by the Food and Drug Administration. Noroxin is a fluorinated quinolone derivative structurally related to nalidixic acid (NegGram, Winthrop/Breon, New York, New York). Nalidixic acid was originally synthesized in 1962 and is the prototype of a class of drugs known as quinolones. When compared with nalidixic acid, norfloxacin has a quinolone ring in place of a 1,8-napthyridine molecule. The addition of a 1-piperazinyl group at the 7-position of the quinolone ring confers antipseudomonal activity
Learn more about subscription options.
Register Now for a free account.
Linville T, Matanin D. Norfloxacin and Warfarin. Ann Intern Med. 1989;110:751-752. doi: 10.7326/0003-4819-110-9-751_2
Download citation file:
Published: Ann Intern Med. 1989;110(9):751-752.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only