John A. Robertson, MD; Isidro B. Salusky, MD; William G. Goodman, MD; Keith C. Norris, MD; Jack W. Coburn, MD
Robertson JA, Salusky IB, Goodman WG, Norris KC, Coburn JW. Sucralfate, Intestinal Aluminum Absorption, and Aluminum Toxicity in a Patient on Dialysis. Ann Intern Med. 1989;111:179-181. doi: 10.7326/0003-4819-111-2-179
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Published: Ann Intern Med. 1989;111(2):179-181.
Aluminum absorption from aluminum-containing phosphate-binding antacids is a major source of aluminum loading in patients on dialysis (1). The aluminum is retained when renal function is impaired, and it has been implicated in the pathogenesis of osteomalacia and encephalopathy in these patients (2). Sucralfate, the basic aluminum salt of sucrose sulfate, contains 21% aluminum by weight (3); it is widely used to treat peptic ulcer disease and gastritis (4). Sucralfate does not alter plasma aluminum levels in normal subjects (5). Aluminum can dissociate, however, from sucralfate at a low pH (6) and become bioavailable. Our case report and study data
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Emergency Medicine, Gastroenterology/Hepatology, Nephrology, Renal Replacement Therapy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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