Elio Roti, MD; Eliana Gardini, MD; Roberta Minelli, MD; Mario Salvi, MD; Giuseppe Robuschi, MD; Lewis E. Braverman, MD
Roti E, Gardini E, Minelli R, Salvi M, Robuschi G, Braverman LE. Methimazole and Serum Thyroid Hormone Concentrations in Hyperthyroid Patients: Effects of Single and Multiple Daily Doses. Ann Intern Med. 1989;111:181-182. doi: 10.7326/0003-4819-111-2-181
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Published: Ann Intern Med. 1989;111(2):181-182.
Thionamide drugs are traditionally administered in divided doses, a treatment schedule recommended in many textbooks of endocrinology and thyroidology. The reason for administering antithyroid drugs in divided doses is that they have a relatively short half-life in serum (1). More recent studies, however, have shown that the antithyroid effect of the thionamides is related to their half-life in the thyroid gland rather than in the serum. It has been reported that methimazole (Tapazole, Eli Lilly and Co., Indianapolis, Indiana) administered to hyperthyroid patients has a half-life in serum of 6.8 hours (2), stays in the thyroid for 20 hours (3),
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Endocrine and Metabolism, Thyroid Disorders.
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