Brian M. O'Connor, MD; Jacqueline S. Clifford, BS; William D. Lawrence, MD; Gerald L. Logue, MD
Cold agglutinin disease may be classified as primary or secondary. Monoclonal IgM (occasionally IgG or IgA) proteins with the ability to bind to erythrocytes below body core temperature are found in the sera of patients with the primary (idiopathic) and secondary forms associated with lymphoproliferative disorders (1). In these disorders mild to moderate hemolytic anemia results from the deposition of complement as the cold agglutinin binds to the erythrocyte in the acral circulation. On exposure to cold, episodes of hemoglobinuria related to marked intravascular hemolysis may occur. Exposure to cold may also produce painful acrocyanosis caused by sludging and deoxygenation
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O'Connor BM, Clifford JS, Lawrence WD, Logue GL. Alpha-Interferon for Severe Cold Agglutinin Disease. Ann Intern Med. 1989;111:255–256. doi: 10.7326/0003-4819-111-3-255
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Published: Ann Intern Med. 1989;111(3):255-256.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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