Andrew C. Dixon, MD; Jeffrey M. Nakamura, MD; Noboru Oishi, MD; Dennis H. Wachi, MD; Osamu Fukuyama, MD
To the Editor: Combination chemotherapy with cisplatin, a vinca alkaloid, and bleomycin has been widely used in the therapy of several malignancies. Recently, various types of vascular toxicity have been reported in patients receiving these drugs. We describe a patient who developed angina pectoris related to the administration of this chemotherapeutic regimen.
A 64-year-old Japanese man with a biopsy-proven recurrence of a squamous cell carcinoma of the oropharynx was treated with cisplatin, 70 mg/m2 body surface area, vincristine, 1.2 mg/m2 body surface area, and bleomycin, 12 units/m2 body surface area, on three separate occasions. Each time, on the morning after
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Dixon AC, Nakamura JM, Oishi N, Wachi DH, Fukuyama O. Angina Pectoris and Therapy with Cisplatin, Vincristine, and Bleomycin. Ann Intern Med. 1989;111:342-343. doi: 10.7326/0003-4819-111-4-342
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Published: Ann Intern Med. 1989;111(4):342-343.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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