John S. Adams, MD; Marie M. Diz, BS; Om P. Sharma, MD
Adams JS, Diz MM, Sharma OP. Effective Reduction in the Serum 1,25-Dihydroxyvitamin D and Calcium Concentration in Sarcoidosis-Associated Hypercalcemia with Short-Course Chloroquine Therapy. Ann Intern Med. 1989;111:437-438. doi: 10.7326/0003-4819-111-5-437
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Published: Ann Intern Med. 1989;111(5):437-438.
The chronic administration of drugs of the 4-amino quinoline class, including quinacrine, chloroquine, and hydroxychloroquine, has been used for many years to effectively manage many of the cutaneous (1) and extracutaneous symptoms (2) of sarcoidosis. More recently chloroquine (3) and hydroxychloroquine (4) were shown to reduce the extrarenal synthesis of 1,25-dihydroxyvitamin D (l,25-(OH)2-D) and to lower the serum calcium concentration and fractional urinary calcium excretion rate in hypercalcemic-hypercalciuric patients with sarcoidosis. These reports (3, 4) claim that the 1,25-(OH)2-D and calcium lowering effect of these drugs requires weeks, if not months, of therapy. However, measurements of the serum
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Endocrine and Metabolism, Nephrology, Fluid and Electrolyte Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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