Michael V. Seidan, MD, PhD
To the Editor: Fiocchi and colleagues (1) recently presented evidence that sera from patients with inflammatory bowel disease killed intestinal epithelial cell-associated component (ECAC) coated erythrocytes in an antibody dependent cellular cytotoxicity assay (ADCC). This cytotoxicity may have been due to antibody recognition of a 137- and 160-kilodalton protein found in the P1 fraction of ECAC. An identical ADCC activity was also seen in a large fraction of asymptomatic family members. Specificity of anti-ECAC activity was demonstrated through almost complete lack of ADCC activity in sera from patients with other gastrointestinal and autoimmune diseases. The authors suggested that the discordance
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Seidan MV. Environmental or Genetic Effects in Inflammatory Bowel Disease. Ann Intern Med. 1989;111:445–446. doi: 10.7326/0003-4819-111-5-445
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Published: Ann Intern Med. 1989;111(5):445-446.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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