Stuart P. Leitner, MD; Paul Greenberg, MD; Linda A. Danieu, MD; Richard A. Michaelson, MD
Leitner SP, Greenberg P, Danieu LA, Michaelson RA. Partial Remission of Carcinoid Tumor in Response to Cyproheptadine. Ann Intern Med. 1989;111:760-761. doi: 10.7326/0003-4819-111-9-760
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Published: Ann Intern Med. 1989;111(9):760-761.
The malignant carcinoid syndrome of episodic flushing and diarrhea occurs in association with carcinoid tumors and an elevated urinary level of the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA) (1). Treatment is often directed specifically at diminishing the tumor bulk and includes surgical resection, hepatic artery occlusion, or chemotherapy. Cyproheptadine, a serotonin and histamine antagonist, is often useful in palliating symptoms of the carcinoid syndrome but is not considered to have specific antitumor activity (2). We used cyproheptadine to treat a patient with the carcinoid syndrome. The patient had both symptomatic improvement and an objective partial remission, documented by a fall in
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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