Patrick Marcellin, MD; Michèle Martinot-Peignoux, BS; Marie-Anne Loriot, PhD; Emile Giostra, MD; Nathalie Boyer, MD; Valérie Thiers, BS; Jean-Pierre Benhamou, MD
Marcellin P, Martinot-Peignoux M, Loriot M, Giostra E, Boyer N, Thiers V, et al. Persistence of Hepatitis B Virus DNA Demonstrated by Polymerase Chain Reaction in Serum and Liver after Loss of HBsAg Induced by Antiviral Therapy. Ann Intern Med. 1990;112:227-228. doi: 10.7326/0003-4819-112-3-227
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Published: Ann Intern Med. 1990;112(3):227-228.
The polymerase chain reaction is a method of amplification of nucleic acids (1) that allows the detection of a very small amount of hepatitis B virus DNA (HBV-DNA), not detected by usual slot-blot or dot-blot hybridization (2-4). The presence of HBV-DNA has been previously shown using the polymerase chain reaction in the serum of patients with chronic hepatitis in the absence of serum hepatitis B surface antigen (HBsAg) (3, 4). We looked for HBV-DNA using the polymerase chain reaction in the serum, the mononuclear blood cells, and liver of two patients with chronic hepatitis B who seroconverted from HBsAg to
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Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Viral Hepatitis.
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