Charles H. Adler, MD, PhD; Steven L. Galetta, MD
Whipple disease is a chronic, systemic disorder resulting in steatorrhea, weight loss, arthralgias, fever, and neurologic symptoms (1). Central nervous system manifestations may occur without systemic involvement (2-4), and include headache, seizures, meningitis, myoclonus, dementia, and supranuclear ophthalmoplegia (1-4). A unique, possibly pathognomonic, movement disorder, involving a slow (1 Hz) convergent-divergent pendular nystagmus, associated with synchronous, rhythmic movements of the mouth and other body parts, has been called oculomasticatory or oculo-facial-skeletal myorhythmia. It has previously been reported in six patients with biopsy-proven Whipple disease (5-9). We report a patient with Whipple disease with amnesia, meningitis, supranuclear ophthalmoparesis, and oculo-facial-skeletal myorhythmia
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Adler CH, Galetta SL. Oculo-Facial-Skeletal Myorhythmia in Whipple Disease: Treatment with Ceftriaxone. Ann Intern Med. 1990;112:467–469. doi: 10.7326/0003-4819-76-3-112-6-467
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Published: Ann Intern Med. 1990;112(6):467-469.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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