George L. Bakris, MD
Recent studies in hypertensive, diabetic rats have shown that angiotensin-converting enzyme inhibitors reduce urinary protein excretion and preserve renal function to a greater extent than other antihypertensive agents (1, 2). The effects of calcium channel antagonists on urinary protein excretion and renal hemodynamics vary (3, 4). The renal hemodynamic effects of diltiazem, however, have been shown to be similar to angiotensin-converting enzyme inhibitors (5, 6). We did a prospective crossover trial with diltiazem or lisinopril in eight diabetic, hypertensive patients with nephrotic-range proteinuria to compare the renal effects of these agents.
Eight noninsulin-dependent diabetic patients (three men
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Bakris GL. Effects of Diltiazem or Lisinopril on Massive Proteinuria Associated with Diabetes Mellitus. Ann Intern Med. 1990;112:707–708. doi: 10.7326/0003-4819-112-9-707
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Published: Ann Intern Med. 1990;112(9):707-708.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hypertension.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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