Gary P. Holmes, MD; Julia K. Hilliard, PhD; Karl C. Klontz, MD; Angus H. Rupert, MD; Christine M. Schindler, MD; Eva Parrish, RN; D. Gary Griffin, MD; George S. Ward, DVM; Norman D. Bernstein, MD; Terrell W. Bean, MD; Michael R. Ball; James A. Brady; Michael H. Wilder, MD; Jonathan E. Kaplan, MD
Holmes GP, Hilliard JK, Klontz KC, Rupert AH, Schindler CM, Parrish E, et al. B Virus (Herpesvirus simiae) Infection in Humans: Epidemiologic Investigation of a Cluster. Ann Intern Med. 1990;112:833-839. doi: 10.7326/0003-4819-112-11-833
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Published: Ann Intern Med. 1990;112(11):833-839.
A cluster of four cases of symptomatic B virus infection in humans occurred in Pensacola, Florida, in March 1987. Three cases occurred in persons who worked with monkeys at a research facility, and the fourth resulted from apparent autoinoculation through use of a nonprescription skin cream. Contact tracing identified 159 persons who may have been exposed to B virus (21 had been exposed to monkeys at the facility and 138 had been exposed to one or more of the case-patients), but no further cases were identified. Comparisons of restriction endonuclease patterns from B virus isolates linked two of the three cases in monkey handlers to one clinically ill monkey and the other to a second, healthy monkey. Three risk factors for human infection were identified: nonuse of mechanical or chemical restraints for monkeys before handling, nonuse of available protective gear, and direct viral inoculation through the application of a topical medication.
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