Dilip R. Karnad, MD; G.H. Tilve, MD
To the Editors: Malignant tumors undergo necrosis or ulceration when cell division outgrows vascular supply (1), and the hypoxic necrotic region then provides optimal conditions for growth of anaerobic clostridia (2, 3). Experimental injection of spores of Clostridium tetani can cause tetanus in mice with necrotic malignant tumors (2). However, tetanus in patients with malignancies is not known. We report the cases of seven such patients.
A 50-year-old man with dysphagia had an ulcerated squamous cell carcinoma on the posterior third of his tongue. He developed moderately severe tetanus 1 month after onset of dysphagia. Patient 2, a 58-year-old woman,
Learn more about subscription options.
Register Now for a free account.
Karnad DR, Tilve G. Tetanus from Ulcerated Tumors. Ann Intern Med. 1990;113:170-171. doi: 10.7326/0003-4819-113-2-170_2
Download citation file:
Published: Ann Intern Med. 1990;113(2):170-171.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only