Brian L. Strom, MD, MPH; Peter Tugwell, MD, MSc
Strom BL, Tugwell P. Pharmacoepidemiology: CurrentStatus, Prospects, and Problems. Ann Intern Med. 1990;113:179-181. doi: 10.7326/0003-4819-113-3-179
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Published: Ann Intern Med. 1990;113(3):179-181.
Modern medicine is now blessed with drug therapies that are much more powerful than before, enabling us to provide much better medical care but also to do much greater harm. Adverse drug reactions are a major source of morbidity (1) and are potentially preventable. Adverse drug reactions have been reported to cause 3% to 6% of all medical admissions (2) and as many as 160 000 deaths each year (3).
After preclinical animal testing, drugs undergo three phases of clinical testing. Generally, between 500 and 3000 patients are exposed to a drug before marketing, in order to be able to
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