Henry L. Harrell, MD
To the editors: Ulcerations on the lower legs occur in up to 75% of adults with sickle cell anemia. Secondary infections are common, and there is often painful limitation of ankle motion. Treatment regimens generally have been unsatisfactory (1, 2). The pathophysiology leading to these lesions is not known with certainty, although the lesions are assumed to result from ischemia due to reduced or obstructed flow in the microcirculation.I have followed a 32-year-old man with homozygous sickle cell anemia for the past 17 years. At 27 years of age, he developed constant ulceration on both ankles and feet. The ulceration
Learn more about subscription options.
Register Now for a free account.
Harrell HL. L-Carnitine for Leg Ulcers. Ann Intern Med. 1990;113:412. doi: 10.7326/0003-4819-113-5-412_1
Download citation file:
Published: Ann Intern Med. 1990;113(5):412.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only