H.E. van der Wiel, MD; C.H. Polman, MD; J.C. Netelenbos, MD
van der Wiel H, Polman C, Netelenbos J. Corticosteroids and Bone Mass. Ann Intern Med. 1990;113:560. doi: 10.7326/0003-4819-113-7-560_2
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Published: Ann Intern Med. 1990;113(7):560.
To the Editors: In response to the excellent review on glucocorticoid-induced osteoporosis by Lukert and Raisz (1), we want to draw attention to our small study. We prospectively studied bone mineral measurements in eight patients (mean age, 43.1 ±9.3 years; seven men and one woman) with a progressive form of multiple sclerosis who were treated with high-dose intravenous methylprednisolone pulse therapy, 500 mg every month. All patients definitely had multiple sclerosis according to the Poser criteria (2). Bone mineral measurements were done before the first infusion and after the third and the sixth infusions. We presumed that during chronic corticosteroid
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