Arthur L. Hooberman, MD
Hooberman AL. Molecular Genetics of Chronic Myelogenous Leukemia. Ann Intern Med. 1990;113:898-899. doi: 10.7326/0003-4819-113-11-898
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Published: Ann Intern Med. 1990;113(11):898-899.
To the Editors: The editorial by Epner and Koeffler (1) about molecular genetic analysis of chronic myelogenous leukemia contains some misleading points. First, the youngest age for a Philadelphia-chromosome (Ph1)-positive patient with acute lymphocytic leukemia who has a chromosome 22 breakpoint within the breakpoint cluster region (bcr) is not 14 years as they stated, but 12 years (2). Further, because relatively few pediatric patients with acute lymphocytic leukemia have had molecular studies, it seems to be premature to make absolute statements about the age limit under which bcr rearrangements are not seen. Second, they state that Ph1-positive patients with acute
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