Bryan K. Demarie, MD; George L. Bakris, MD
Studies in various animal models of renal dysfunction show that urinary protein excretion is partly determined by glomerular capillary pressure (1-5). Further, clinical studies have shown that nifedipine, an agent that does not alter glomerular capillary pressure, increases urinary protein excretion and leads to renal dysfunction (6-8). In addition, diltiazem, an agent that lowers glomerular capillary pressure, decreases urinary protein excretion in a manner similar to that of angiotensin-converting enzyme inhibitors in diabetic patients with renal insufficiency and hypertension (9). We conducted a prospective crossover trial to evaluate the effects of diltiazem and nifedipine on urinary protein excretion in diabetic,
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Demarie BK, Bakris GL. Effects of Different Calcium Antagonists on Proteinuria Associated with Diabetes Mellitus. Ann Intern Med. 1990;113:987-988. doi: 10.7326/0003-4819-113-12-987
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Published: Ann Intern Med. 1990;113(12):987-988.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hypertension.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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