Koji Yokokawa, MD; Hideki Tahara, MD; Masakazu Kohno, MD; Koh-ichi Murakawa, MD; Kenichi Yasunari, MD; Koichi Nakagawa, MD; Toshio Hamada, MD; Shuzo Otani, MD; Masashi Yanagisawa, MD; Tadanao Takeda, MD
Endothelin-1, a potent vasoconstrictor peptide that has recently been isolated from the supernatant of cultured porcine aortic endothelial cells (1), is involved in some vascular disorders (2). Malignant hemangioendothelioma, a rare malignant vascular neoplasm, is characterized by intravascular proliferation of atypical endothelium. Patients with malignant hemangioendothelioma usually die with metastases to the lungs and brain or with vascular involvement in the brain or coronary arteries (3). We measured plasma levels of endothelin-1 in two patients with malignant hemangioendothelioma of the scalp before and after surgical excision.
Endothelin-1 was extracted from EDTA-plasma or prepared tissue samples (4) through
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Yokokawa K, Tahara H, Kohno M, Murakawa K, Yasunari K, Nakagawa K, et al. Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma. Ann Intern Med. 1991;114:213–215. doi: 10.7326/0003-4819-114-3-213
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Published: Ann Intern Med. 1991;114(3):213-215.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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