F.W. Busch, MD; H. Schmidt, MD; B. Steinke, MD
Busch F, Schmidt H, Steinke B. Alpha-Interferon for the Hypereosinophilic Syndrome. Ann Intern Med. 1991;114:338-339. doi: 10.7326/0003-4819-114-4-338_2
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Published: Ann Intern Med. 1991;114(4):338-339.
To the Editors: Zielinski and Lawrence (1) reported the case of a patient with the hypereosinophilic syndrome who was successfully treated with interferon-á. Independently of their studies, we initiated interferon-á therapy in two patients with this syndrome who could not be managed with conservative treatment. Both patients had the syndrome according to standard criteria (2), and chromosomal abnormalities had been ruled out by repeated cytogenetic analyses (courtesy of Professor Fonatsch, Lübeck, Federal Republic of Germany). Organ involvement included restrictive endomyocardiopathy and right ventricular failure in both patients. Patient A, a 48-year-oldman, also developed recurring diarrhea that was interpreted as a
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