J.P. Deslypere, MD; A. Vermeulen, MD
Deslypere J, Vermeulen A. Rhabdomyolysis and Simvastatin. Ann Intern Med. 1991;114:342. doi: 10.7326/0003-4819-114-4-342_1
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Published: Ann Intern Med. 1991;114(4):342.
To the Editors: Lovastatin, a new cholesterol-lowering drug inhibiting the activity of 3-hydroxy-3 methylglutaryl-CoA reductase can cause myositis and elevation in creatine kinase levels in a small proportion (< 0.5%) of patients (1-4). Severe muscle damage and acute renal failure have been described in association with lovastatin use. The incidence of these outcomes appears to be greatly increased by concomitant therapy with gemfibrozil and nicotinic acid and even more by immunosuppressive therapy including therapy with cyclosporine (1-4).These complications have not been described in association with the use of simvastatin (Zocor, Merck Sharp & Dohme, West Point, Pennsylvania), another more recently
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Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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