Maria H. Sjogren, MD, MPH; Charles H. Hoke, MD; Leonard N. Binn, PhD; Kenneth H. Eckels, PhD; Doria R. Dubois, PhD; Lionel Lyde; Amy Tsuchida, MD; Stanley Oaks, PhD; Ruth Marchwicki, BS; Wayne Lednar, MD, PhD; Robert Chloupek, MD; John Ticehurst, MD; William H. Bancroft, MD
Although hepatitis A is a disease without chronic sequelae, it is associated with serious morbidity in adults. An inactivated hepatitis A vaccine prepared at the Walter Reed Army Institute of Research was observed to successfully immunize owl monkeys (1). In a preliminary study, this vaccine was given to eight men, all of whom developed neutralizing antibody to hepatitis A virus (anti-HAV) (2). The present study was designed to confirm the vaccine's immunogenicity, to obtain additional evidence of vaccine safety, and to establish a practical dosing schedule.
Forty-two male volunteers, 18 to 50 years of age, were enrolled from among
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Sjogren MH, Hoke CH, Binn LN, Eckels KH, Dubois DR, Lyde L, et al. Immunogenicity of an Inactivated Hepatitis A Vaccine. Ann Intern Med. 1991;114:470-471. doi: 10.7326/0003-4819-114-6-470
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Published: Ann Intern Med. 1991;114(6):470-471.
Gastroenterology/Hepatology, Infectious Disease, Prevention/Screening, Vaccines/Immunization, Viral Hepatitis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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