Andrew C. Rankin, MD; Brian A. McGovern, MD
Rankin AC, McGovern BA. Adenosine or Verapamil for the Acute Treatment of Supraventricular Tachycardia?. Ann Intern Med. 1991;114:513-515. doi: 10.7326/0003-4819-114-6-513
Download citation file:
Published: Ann Intern Med. 1991;114(6):513-515.
Adenosine, an endogenous, rapidly metabolized, purine nucleoside, was approved recently by the Food and Drug Administration for intravenous use in patients with paroxysmal supraventricular tachycardia. It acts through extracellular adenosine receptors and causes transient slowing or block of atrioventricular nodal conduction (1, 2). This process results in the termination of most supraventricular tachycardias that use a re-entrant circuit that includes the atrioventricular node (2-5). Adenosine's duration of action in humans is typically less than 1 minute, because of rapid cellular uptake and enzymatic breakdown (6). This brevity of action is an advantage, because adverse effects should be correspondingly brief. Adenosine
Learn more about subscription options.
Register Now for a free account.
Cardiology, Rhythm Disorders and Devices.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only