Robert G. Berger, MD; Susan J. Knox, MD, PhD; Ronald Levy, MD; Jeffrey L. Sklar, MD, PhD; Philip Cohen, MD; Thomas Reichert, MD, PhD
We report the case of a patient with mycosis fungoides who developed a progressive arthropathy from malignant synovial infiltration. The arthropathy responded to treatment with a chimeric, human-murine monoclonal antibody against T-helper cells.
At 39 years of age, this previously healthy woman developed a rash over her abdomen and, subsequently, over her thighs and arms. The rash was characterized by hyperkeratotic, erythematous plaques. Two years later, she developed a symmetric, nonerosive small hand-joint arthritis. Tests for rheumatoid factor and antinuclear antibody had negative results.
Over the next year, the patient's rheumatic and cutaneous symptoms responded to neither hydroxychloroquine
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Berger RG, Knox SJ, Levy R, Sklar JL, Cohen P, Reichert T. Mycosis Fungoides Arthropathy. Ann Intern Med. 1991;114:571–572. doi: 10.7326/0003-4819-114-7-571
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Published: Ann Intern Med. 1991;114(7):571-572.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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