J. L. Ambrus, MD, PhD; K. C. Chadha, PhD; J. L. Ambrus, MD
To the Editors: In previous reports, we described nonantibody-type interferon inhibitors in patients with systemic lupus erythematosus (1). We are in the process of isolating and identifying these inhibitors and of studying their mechanisms of action. Similar inhibitors were found in the circulation in patients with some neoplastic and viral diseases including the acquired immunodeficiency syndrome (AIDS) (2-4). These inhibitors were not found in normal persons.
We have recently studied a patient with advanced, biopsy-proved Wegner granulomatosis and vasculitis. Using previously reported methods to assay interferon inhibitory activity (3, 4), we found that this patient had 35 Roswell Park Memorial
Learn more about subscription options.
Register Now for a free account.
Ambrus JL, Chadha KC, Ambrus JL. Interferon Inhibitors. Ann Intern Med. 1991;114:606-607. doi: 10.7326/0003-4819-114-7-606_2
Download citation file:
Published: Ann Intern Med. 1991;114(7):606-607.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only