Samuel A. Bozzette, MD; Robert A. Larsen, MD; Joseph Chiu, MD; Mary Ann E. Leal, MD; Jeremiah G. Tilles, MD; Douglas D. Richman, MD; John M. Leedom, MD; J. Allen McCutchan, MD
Bozzette SA, Larsen RA, Chiu J, Leal MAE, Tilles JG, Richman DD, et al. Fluconazole Treatment of Persistent Cryptococcus neoformans Prostatic Infection in AIDS. Ann Intern Med. 1991;115:285-286. doi: 10.7326/0003-4819-115-4-285
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Published: Ann Intern Med. 1991;115(4):285-286.
The prostate gland is a common site for persistent and recurrent Cryptococcus neoformans infection after amphotericin B therapy for cryptococcal meningitis in patients with the acquired immunodeficiency syndrome (AIDS) (1, 2). Additional prolonged amphotericin B therapy up to total doses of six grams has not led to suppression of cryptococcuria, and discontinuation of therapy has led to recurrence of disseminated infection (1 and unpublished data). In seeking more effective therapies, we prospectively studied patients treated with fluconazole, an orally absorbed triazole that has excellent tissue penetration and antifungal activity in cryptococcal infection (2-5).
We studied 14 patients
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