Marshall S. Stanton, MD
Stanton MS. Disopyramide and Inducible Arrhythmias. Ann Intern Med. 1991;115:409. doi: 10.7326/0003-4819-115-5-409_1
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Published: Ann Intern Med. 1991;115(5):409.
To the Editors: Singh (1), in a recent review article on ventricular arrhythmias, lists as unknown the efficacy of disopyramide in suppressing ventricular tachycardia and ventricular fibrillation at programmed electrical stimulation. At least 14 studies have addressed this question. The largest study was done by Lerman and colleagues (2), who studied 50 patients with inducible sustained ventricular tachycardia or ventricular fibrillation. These investigators found that disopyramide rendered 34% of the patients noninducible. Studies involving crossover drug testing have shown disopyramide to be equivalent to quinidine (3) and superior to mexiletine (4) for rendering ventricular tachyarrhythmias noninducible.
Singh also stated that
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