Ursula Kronawitter, MD; Johannes R. Bogner, MD; Frank D. Goebel, MD
Kronawitter U, Bogner JR, Goebel FD. Pentamidine Prophylaxis of Pneumocystis carinii Pneumonia. Ann Intern Med. 1991;115:497-498. doi: 10.7326/0003-4819-115-6-497_2
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Published: Ann Intern Med. 1991;115(6):497-498.
To the Editors: Aerosolized pentamidine became available about 2 years ago, but the optimal dosage for prophylaxis of Pneumocystis carinii pneumonia has not yet been determined. We assessed the effects of a 300-mg dose of pentamidine inhaled every 2 weeks, adding 1 mL of salbutamol to the pentamidine to prevent bronchoconstriction.
Our study included 128 consecutive human immunodeficiency virus (HIV)-infected patients with the acquired immunodeficiency syndrome (AIDS) or a CD4 cell count of less than 250/µL. Within 8 weeks, 19 patients were withdrawn from study because of noncompliance and 2 patients died. Autopsy revealed P. carinii pneumonia in one patient.
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Infectious Disease, Pulmonary/Critical Care, Pneumonia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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