Terence Hadley, MD; Benjamin Djulbegovic, MD, PhD
Patients with hemophilia B can be effectively treated with prothrombin complex concentrates (factor IX complex) that contain factors II, VII, IX, and X (1). A complication of therapy with factor IX complex is disseminated intravascular coagulation, attributed in part to activated factors in factor IX complex (2). We describe a patient with hemophilia B who developed disseminated intravascular coagulation while being treated with factor IX complex for a cerebellar hemorrhage. The patient's therapy was switched from factor IX complex to monoclonal antibody-purified factor IX (Mononine, Armour, Blue Bell, Pennsylvania), and the disseminated intravascular coagulation resolved.
Learn more about subscription options.
Register Now for a free account.
Hadley T, Djulbegovic B. Disseminated Intravascular Coagulation after Factor IX Complex Resolved Using Purified Factor IX Concentrate. Ann Intern Med. 1991;115:621-622. doi: 10.7326/0003-4819-115-8-621
Download citation file:
Published: Ann Intern Med. 1991;115(8):621-622.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only