Terence Hadley, MD; Benjamin Djulbegovic, MD, PhD
Patients with hemophilia B can be effectively treated with prothrombin complex concentrates (factor IX complex) that contain factors II, VII, IX, and X (1). A complication of therapy with factor IX complex is disseminated intravascular coagulation, attributed in part to activated factors in factor IX complex (2). We describe a patient with hemophilia B who developed disseminated intravascular coagulation while being treated with factor IX complex for a cerebellar hemorrhage. The patient's therapy was switched from factor IX complex to monoclonal antibody-purified factor IX (Mononine, Armour, Blue Bell, Pennsylvania), and the disseminated intravascular coagulation resolved.
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Hadley T, Djulbegovic B. Disseminated Intravascular Coagulation after Factor IX Complex Resolved Using Purified Factor IX Concentrate. Ann Intern Med. 1991;115:621–622. doi: 10.7326/0003-4819-115-8-621
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Published: Ann Intern Med. 1991;115(8):621-622.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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