Ian Joffe, MD
To the editors: Kadunce and colleagues (1) report that cigarette smoking is an independent risk factor for the development of facial wrinkles, although the mechanism is unclear. As noted by the authors, only a subgroup of subjects (27.5%) with a smoking history of more than 50 pack-years were severely wrinkled, a relation similar to that between smoking and chronic obstructive pulmonary disease, in which only 26% of heavy smokers developed airway obstruction. An inverse relation has been reported among vitamin A consumption, retinol levels, and the subsequent development of lung cancer in men (2). Smoking might contribute to the increased
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Joffe I. Cigarette Smoking and Facial Wrinkling. Ann Intern Med. 1991;115:659-660. doi: 10.7326/0003-4819-115-8-659
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Published: Ann Intern Med. 1991;115(8):659-660.
Cardiology, Coronary Risk Factors, Smoking, Tobacco, Alcohol, and Other Substance Abuse.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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