Keith Henry, MD; Scott Rathgaber, MD; Christopher Sullivan, MD; Kathleen McCabe, RN
Megestrol acetate has been reported to be a relatively nontoxic drug (1, 2) that is efficacious in the treatment of cachexia associated with the acquired immune deficiency syndrome (AIDS) (3). We report the case of a patient with AIDS who developed diabetes mellitus requiring insulin therapy 13 weeks after beginning megestrol therapy and who experienced an exacerbation of his diabetes when rechallenged with megestrol.
A 46-year-old man had been diagnosed with AIDS 2.5 years earlier when a skin biopsy specimen showed Kaposi sarcoma. His treatment regimen is summarized in Figure 1. Before beginning therapy with megestrol acetate, his
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Henry K, Rathgaber S, Sullivan C, McCabe K. Diabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and Cachexia. Ann Intern Med. 1992;116:53-54. doi: 10.7326/0003-4819-116-1-53
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Published: Ann Intern Med. 1992;116(1):53-54.
HIV, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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