Russell W. Harland, MD; Carl G. Becker, MD; James C. Brandes, MD; Claire Fritsche, MD; David Y. Rosenzweig, MD
Idiopathic immunoglobulin A (IgA) nephropathy (Berger disease) is a syndrome characterized by mesangial proliferative glomerulonephritis with prominent mesangial deposits of IgA (1, 2). Clinical features of this syndrome include a prolonged course of persistent microscopic hematuria, intermittent macroscopic hematuria, and variable proteinuria. Typically, episodes of gross hematuria are preceded by gastroenteritis (3) or pulmonary symptoms (1, 2). Deposition of IgA in areas other than the kidney and skin has not been well described. It has been estimated that between 10% and 20% of patients progress to end-stage renal failure (1, 2).
Although the pathogenesis of IgA nephropathy is unclear, most investigators
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Harland RW, Becker CG, Brandes JC, Fritsche C, Rosenzweig DY. Immunoglobulin A (IgA) Immune Complex Pneumonitis in a Patient with IgA Nephropathy. Ann Intern Med. 1992;116:220-222. doi: 10.7326/0003-4819-116-3-220
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Published: Ann Intern Med. 1992;116(3):220-222.
Autoimmune Kidney Disease, Infectious Disease, Nephrology, Pneumonia, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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