Samuel W. Needleman, MD; James Sorace, MD; Hipolito Poussin-Rosillo, MD
Needleman SW, Sorace J, Poussin-Rosillo H. Low-Dose Splenic Irradiation in the Treatment of Autoimmune Thrombocytopenia in HIV-infected Patients. Ann Intern Med. 1992;116:310-311. doi: 10.7326/0003-4819-116-4-310
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Published: Ann Intern Med. 1992;116(4):310-311.
Autoimmune thrombocytopenic purpura (AITP) is one of many compli-cations associated with human immunodeficiency virus (HIV) type-1 infections (1, 2). Circulating immune complexes (3), antiplatelet antibodies (4, 5), and anti-idiotype antibody formation (6) have each been suggested to play a role in its pathogenesis.
Treatment of AITP in HIV-infected patients is difficult for two reasons. Established therapies for AITP (that is, corticosteroids) may be associated with an increased risk in patients with HIV infection because they superimpose an additional immunosuppressive burden and thus might increase the rate of opportunistic infection (7). Splenectomy, although offering remission rates in HIV-infected patients comparable to
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Hematology/Oncology, Infectious Disease, HIV, Platelet Disorders, Coagulopathies.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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