Ahvie Herskowitz, MD; Sharon B. Willoughby, MA; Kenneth L. Baughman, MD; Steven P. Schulman, MD; John D. Bartlett, MD
Symptomatic congestive heart failure has been described as part of the spectrum of human immunodeficiency virus (HlV)-related cardiac disease (1-3). Echocardiographic studies have further documented dilated cardiomyopathy in 11% to 22% of HIV-infected adults (4, 5).
The direct etiologic role of HIV infection in cardiomyopathy is controversial. In-situ hybridization studies have failed to show HIV genomic material in endomyocardial biopsy samples taken from patients with HIV-associated myocarditis and clinically established congestive heart failure (6). Rare infected myocytes have, however, been shown using similar techniques in autopsy specimens from patients without heart disease (7). Other etiologies should be considered, such as
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Herskowitz A, Willoughby SB, Baughman KL, Schulman SP, Bartlett JD. Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases. Ann Intern Med. 1992;116:311-313. doi: 10.7326/0003-4819-116-4-311
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Published: Ann Intern Med. 1992;116(4):311-313.
Cardiology, Infectious Disease.
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