Daniel Brookoff, MD, PhD; Rosemary Polomano, MSN
▪ Objective: To assess the effect of a structured analgesic regimen on hospital use by patients with sickle cell disease.
▪ Intervention: Intravenous and oral controlled-release morphine was used instead of intramuscular meperidine and short-acting oral opioids for the treatment of sickle cell pain.
▪ Design: Time series in which emergency and admission records for four 6-month periods before and two 6-month periods after the institution of the new analgesic protocol were reviewed.
▪ Setting: Inner-city university hospital providing care for adults with sickle cell disease.
▪ Patients: All patients (an average of 50) who used the emergency department or the inpatient medical service for treatment of sickle cell crisis during the study periods.
▪ Measurements and Main Results: The number of admissions for sickle cell pain decreased by 44%, total inpatient days by 57%, length of hospital stay by 23%, and the number of emergency department visits by 67% after initiation of the morphine protocol. Hospital use remained at these lower levels one year later. Similar declines were seen for a subset of 15 patients who had a history of frequent admissions for sickle cell pain and who used this hospital exclusively and accounted for more than half of the admissions for sickle cell disease.
▪ Conclusion: A pain-control program modeled on regimens used to treat chronic cancer pain reduced hospital use by adult patients with sickle cell pain.
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Brookoff D, Polomano R. Treating Sickle Cell Pain like Cancer Pain. Ann Intern Med. 1992;116:364–368. doi: 10.7326/0003-4819-116-5-364
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Published: Ann Intern Med. 1992;116(5):364-368.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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