Dietmar Fuchs, PhD; Günter Weiss, MD; Helmut Wachter, PhD
Fuchs D, Weiss G, Wachter H. Anemia of Chronic Disease: A Misnomer?. Ann Intern Med. 1992;116:520-521. doi: 10.7326/0003-4819-116-6-520
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Published: Ann Intern Med. 1992;116(6):520-521.
To the Editors: The editorial by Schilling (1) was very stimulating. Chronic inflammation is very often the underlying mechanism of hypoferric anemia in patients. Chronic immune stimulation appears to cause changes in iron metabolism. In patients with both gynecologic and hematologic neoplasias, we found significant inverse correlations between hemoglobin levels and parameters of immune stimulation, such as gammainterferon and neopterin (2, 3). Large amounts of the latter compound are produced by human macrophages after stimulation with gamma-interferon (4). As for iron metabolism, we found again inverse correlations among levels of serum iron, transferrin, and iron-binding capacity and neopterin levels as
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